| Date | Opponent | Location | Time | TV |
 |
||||
| 09/01/12 | vs. Eastern Kentucky | WEST LAFAYETTE, IN | 3:30 p.m. ET | BTN |
| 09/08/12 | vs. Notre Dame | South Bend, IN | 3:30 p.m. ET | NBC |
| 09/15/12 | vs. Eastern Michigan | WEST LAFAYETTE, IN | 12:00 p.m. ET | BTN |
| 09/29/12 | vs. Marshall | WEST LAFAYETTE, IN | 3:15 p.m ET | TBA |
| 10/06/12 | vs. Michigan | WEST LAFAYETTE, IN | 4:00 p.m. ET | BTN |
| 10/13/12 | vs. Wisconsin (Homecoming) | WEST LAFAYETTE, IN | 12:00 p.m. ET | TBA |
| 10/20/12 | at Ohio State | Columbus, OH | 12:00 p.m. ET | ABC, ESPN2 |
| 10/27/12 | at Minnesota | MINNEAPOLIS | 3:30 p.m. ET | BTN |
| 11/03/12 | vs. Penn State | WEST LAFAYETTE, IN | 3:30 p.m. ET | ESPNU |
| 11/10/12 | at Iowa | Iowa City, IA | 12:00 p.m. ET | BTN |
| 11/17/12 | at Illinois (Purdue Cannon Game) | Champaign, IL | 2:30 p.m. CT | BTN |
| 11/24/12 | vs. Indiana (Old Oaken Bucket Game) | WEST LAFAYETTE, IN | 12:00 p.m. ET | BTN |
| Big Ten Championship Game | ||||
| 12/01/12 | Big Ten Championship Game | Indianapolis, Ind. | TBA | TBA |
Purdue University