| Date | Opponent | Location | Time | TV |
 |
||||
| 09/01/12 | vs. Ohio University | STATE COLLEGE, PA | 12:00 p.m. ET | ESPN |
| 09/08/12 | at Virginia | Charlottesville, VA | 12:00 p.m. ET | ABC |
| 09/15/12 | vs. Navy | STATE COLLEGE, PA | 3:30 p.m. ET | ABC/ESPN2 |
| 09/22/12 | vs. Temple | STATE COLLEGE, PA | 12:00 p.m. ET | TBA |
| 09/29/12 | at Illinois | Champaign, IL | 12:00 p.m. ET | TBA |
| 10/06/12 | vs. Northwestern (Homecoming) | STATE COLLEGE, PA | 12:00 p.m. ET | TBA |
| 10/20/12 | at Iowa | Iowa City, IA | 8:00 p.m. ET | BTN |
| 10/27/12 | vs. Ohio State | STATE COLLEGE, PA | 5:30 p.m.ET | ESPN/ESPN2 |
| 11/03/12 | at Purdue | West Lafayette, IN | 3:30 p.m. ET | ESPNU |
| 11/10/12 | at Nebraska | Lincoln, NE | 2:30 p.m. ET | ABC, ESPN2 |
| 11/17/12 | vs. Indiana | STATE COLLEGE, PA | 12:00 p.m. ET | BTN |
| 11/24/12 | vs. Wisconsin | STATE COLLEGE, PA | 3:30 p.m. ET | ABC/ ESPN/ESPN2 |
| Big Ten Championship Game | ||||
| 12/01/12 | Big Ten Championship Game | Indianapolis, Ind. | TBA | TBA |
Penn State University