| Date | Opponent | Location | Time | TV |
 |
||||
| 09/01/12 | vs. Miami (OH) | COLUMBUS, OH | 12:00 p.m. ET | BTN |
| 09/08/12 | vs. Central Florida | COLUMBUS, OH | 12:00 p.m. ET | ESPN2 |
| 09/15/12 | vs. California | COLUMBUS, OH | 12:00 p.m. ET | ABC |
| 09/22/12 | vs. UAB | COLUMBUS, OH | 12:00 p.m. ET | TBA |
| 09/29/12 | at Michigan State | East Lansing, MI | 3:30 p.m. ET | TBA |
| 10/06/12 | vs. Nebraska (Homecoming) | COLUMBUS, OH | 8:00 p.m. ET | ABC, ESPN or ESPN2 |
| 10/13/12 | at Indiana | Bloomington, IN | 8:00 p.m. ET | BTN |
| 10/20/12 | vs. Purdue | COLUMBUS, OH | 12:00 p.m. ET | ABC, ESPN2 |
| 10/27/12 | at Penn State | State College, PA | 5:30 p.m. ET | ABC, ESPN or ESPN2 |
| 11/3/12 | vs. Illinois (Illibuck Trophy Game) | COLUMBUS, OH | 3:30 p.m. ET | ESPN |
| 11/17/12 | at Wisconsin | Madison, WI | 3:30 p.m. ET | ABC or ESPN2 |
| 11/24/12 | vs Michigan (OSU-UM Rivalry Game) | COLUMBUS, OH | 12:00 p.m. ET | ABC |
| Big Ten Championship Game | ||||
| 12/01/12 | Big Ten Championship Game | Indianapolis, Ind. | TBA | TBA |
The Ohio State University