| Date | Opponent | Location | Time | TV |
 |
||||
| 09/01/12 | vs. Alabama | Arlington, Texas | 7:00 p.m. CT | ABC |
| 09/08/12 | vs. Air Force | ANN ARBOR, MI | 3:30 p.m. ET | ABC (ESPN2 mirror) |
| 09/15/12 | vs. Massachusetts | ANN ARBOR, MI | 3:30 p.m. ET | BTN |
| 09/22/12 | at Notre Dame | South Bend, IN | 7:30 p.m. ET | NBC |
| 10/06/12 | at Purdue | West Lafayette, IN | 4:00 p.m. ET | BTN |
| 10/13/12 | vs. Illinois (Homecoming) | ANN ARBOR, MI | 3:30 p.m. ET | ABC |
| 10/20/12 | vs. Michigan State (Paul Bunyan Trophy Game) | ANN ARBOR, MI | 3:30 p.m. ET | BTN |
| 10/27/12 | at Nebraska | Lincoln, NE | 7:00 p.m. CT | ABC |
| 11/03/12 | at Minnesota (Little Brown Jug Game) | Minneapolis, MN | 11:00 a.m. CT | BTN |
| 11/10/12 | vs. Northwestern | ANN ARBOR, MI | 12:00 p.m. ET | ESPN |
| 11/17/12 | vs. Iowa | ANN ARBOR, MI | 12:00 p.m. ET | ESPN or ESPN2 |
| 11/24/12 | at Ohio State (UM-OSU Rivalry Game) | Columbus, OH | 12:00 p.m. ET | ABC |
| Big Ten Championship Game | ||||
| 12/01/12 | Big Ten Championship Game | Indianapolis, Ind. | TBA | TBA |
University of Michigan