| Date | Opponent / Event | Location | Time | TV |
 |
||||
| 09/01/12 | vs. Indiana State | BLOOMINGTON, IN | 8:00 p.m. ET | BTN |
| 09/08/12 | at Massachusetts | Foxborough, Mass. (Gillette Stadium) | 3:30 p.m. ET | ESPN3 |
| 09/15/12 | vs. Ball State | BLOOMINGTON, IN | 8:00 p.m. ET | BTN |
| 09/29/12 | at Northwestern | Evanston, IL | 12:00 p.m. ET | |
| 10/06/12 | vs. Michigan State (Homecoming) (Old Brass Spittoon Game) |
BLOOMINGTON, IN | 12:00 p.m. ET | |
| 10/13/12 | vs. Ohio State | BLOOMINGTON, IN | 8:00 p.m. ET | BTN |
| 10/20/12 | at Navy | Annapolis, Md. | 3:30 p.m. ET | CBS Sports |
| 10/27/12 | at Illinois | Champaign, IL | 12:00 p.m. ET | ESPN, BTN |
| 11/03/12 | vs. Iowa | BLOOMINGTON, IN | 3:30 p.m. ET | BTN |
| 11/10/12 | vs. Wisconsin | BLOOMINGTON, IN | 12:00 p.m. ET | ESPN2 |
| 11/17/12 | at Penn State | University Park/State College, PA | 12:00 p.m. ET | BTN |
| 11/24/12 | at Purdue (Old Oaken Bucket Game) | West Lafayette, IN | 12:00 p.m. ET | BTN |
| Big Ten Championship Game | ||||
| 12/01/12 | Big Ten Championship Game | Indianapolis, Ind. | TBA | TBA |
Indiana University